Anti-GRIN2B antibodies are used in the immunodetection of the protein glutamate ionotropic receptor NMDA type subunit 2B. In humans, the canonical protein has a reported length of 1484 amino acid residues and a mass of 166.4 kDa. Its subcellular localization is in the cell membrane, lysosomes and cytoplasm. It is notably expressed in the cerebellum. A member of the Glutamate-gated ion channel (TC 1.A.10.1) protein family, GRIN2B is known to be a component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Post-translational modifications have been described, including phosphorylation and glycosylation. The GRIN2B gene has been associated with the disease, Intellectual developmental disorder. Synonyms for this target antigen include EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3, and DEE27. GRIN2B gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.