Anti-GP1BA antibodies are used in the immunodetection of the protein glycoprotein Ib platelet subunit alpha. In humans, the canonical protein has a reported length of 652 amino acid residues and a mass of 71.5 kDa. Its subcellular localization is in the membrane. It is notably expressed in the bone marrow and spleen. GP1BA is known to be involved with cell adhesion and receptor-mediated signaling pathways. Post-translational modifications have been described, including protein cleavage and glycosylation. The GP1BA marker can be used to identify Lung Megakaryocytes.* Synonyms for this target antigen include BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GPIbA, and BDPLT1. GP1BA gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4