Anti-CXCR5 antibodies are used in the immunodetection of the protein C-X-C motif chemokine receptor 5. In humans, the canonical protein has a reported length of 372 amino acid residues and a mass of 42 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the G-protein coupled receptor 1 protein family, CXCR5 is reported to be a cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Post-translational modifications have been described, including glycosylation.
The CXCR5 marker can be used to identify T Follicular Helper Cells and T Follicular Regulatory Cells.* Synonyms for this target antigen include CD185, MDR15, C-X-C chemokine receptor type 5, Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5), and BLR1. CXCR5 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4