Anti-COMT antibodies are used in the immunodetection of the protein catechol-O-methyltransferase. In humans, the canonical protein has a reported length of 271 amino acid residues and a mass of 30 kDa. Its subcellular localization is in the cell membrane and cytoplasm. It is notably widely expressed in many tissue types. A member of the Cation-dependent O-methyltransferase protein family, Comt is known to catalyze the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. The COMT gene has been associated with the disease, Schizophrenia. Synonyms for this target antigen include epididymis secretory sperm binding protein Li 98n, testicular tissue protein Li 42, and HEL-S-98n. COMT gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. A number of Comt antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.