Anti-bisphosphoglycerate mutase antibodies are used for the immunodetection of the protein encoded by the BPGM gene. In humans, the canonical protein has a reported length of 259 amino acid residues and a mass of 30 kDa. It is reported to be expressed in red blood cells. A member of the Phosphoglycerate mutase protein family, it is known to play an important role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG).
The bisphosphoglycerate mutase marker can be used to characterize Late Erythroid Cells.* Other names for this target antigen include ECYT8, 2,3-bisphosphoglycerate mutase, erythrocyte, 2,3-bisphosphoglycerate synthase, 2,3-diphosphoglycerate mutase, and DPGM. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of bisphosphoglycerate mutase antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4