Anti-PKHD1 ciliary IPT domain containing fibrocystin/polyductin antibodies are used for the immunodetection of the protein encoded by the PKHD1 gene. In humans, the canonical protein has a reported length of 4074 amino acid residues and a mass of 446.7 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be highly expressed in the fetal and adult kidney. It is reported to promote ciliogenesis in renal epithelial cells and therefore participates in the tubules formation and/ or ensures the maintenance of the architecture of the lumen of the kidney (By similarity). Post-translational modifications have been described, including N-glycosylation, palmitoylation and protein cleavage. Other names for this target antigen include FCYT, FPC, PKD4, TIGM1, fibrocystin, PKHD1, fibrocystin/polyductin, TIG multiple domains 1, and ARPKD. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.