Anti-SEC61 translocon subunit alpha 2 antibodies are used for the immunodetection of the protein encoded by the SEC61A2 gene. In humans, the canonical protein has a reported length of 476 amino acid residues and a mass of 52.2 kDa. Its subcellular localization is in the ER. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the SecY/SEC61-alpha protein family, it is known to be a component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Other names for this target antigen include SEC61 translocon alpha 2 subunit, Sec61 alpha 2 subunit, Sec61 alpha form 2, protein transport protein Sec61 subunit alpha, sec61 alpha-2, and protein transport protein Sec61 subunit alpha isoform 2. Gene orthologs have been identified in the mouse, rat, bovine, chimpanzee and chicken species.