Anti-VPS33A core subunit of CORVET and HOPS complexes antibodies are used for the immunodetection of the protein encoded by the VPS33A gene. In humans, the canonical protein has a reported length of 596 amino acid residues and a mass of 67.6 kDa. Its subcellular localization is in the cytoplasmic vesicles, lysosomes, and membrane. A member of the STXBP/unc-18/SEC1 protein family, it is reported to play a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. The gene encoding this protein is implicated in Mucopolysaccharidosis-plus syndrome. Other names for this target antigen include VPS33A, CORVET/HOPS core subunit, vacuolar protein sorting 33 homolog A, vacuolar protein sorting 33A, and vacuolar protein sorting-associated protein 33A. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.