Anti-EBF transcription factor 2 antibodies are used for the immunodetection of the protein encoded by the EBF2 gene. In humans, the canonical protein has a reported length of 575 amino acid residues and a mass of 62.7 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the COE protein family, it is reported to be a transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Other names for this target antigen include Collier, Olf and EBF 2, Collier, Olf and EBF transcription factor 2, OLF-1/EBF-LIKE 3, early B cell factor 2, metencephalon-mesencephalnon-olfactory transcription factor 1, and transcription factor COE2. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.