Anti-KRIT1 ankyrin repeat containing antibodies are used for the immunodetection of the protein encoded by the KRIT1 gene. In humans, the canonical protein has a reported length of 736 amino acid residues and a mass of 84.3 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is a known component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). The gene encoding this protein is implicated in Cerebral cavernous malformations. Other names for this target antigen include CCM1, krev interaction trapped protein 1, ankyrin repeat-containing protein Krit1, cerebral cavernous malformations 1 protein, krev interaction trapped 1, and CAM. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.