Anti-ACD shelterin complex subunit and telomerase recruitment factor antibodies are used for the immunodetection of the protein encoded by the ACD gene. In humans, the canonical protein has a reported length of 458 amino acid residues and a mass of 49 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. It is a known component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. The gene encoding this protein is implicated in Dyskeratosis congenita. Other names for this target antigen include POT1 and TIN2-interacting protein, TIN2 interacting protein 1, adrenocortical dysplasia homolog, and adrenocortical dysplasia protein homolog. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species.