Anti-ORC ubiquitin ligase 1 antibodies are used for the immunodetection of the protein encoded by the OBI1 gene. In humans, the canonical protein has a reported length of 726 amino acid residues and a mass of 81.1 kDa. Its subcellular localization is in the chromosomes. It is noted to be involved in DNA replication. Post-translational modifications have been described, including ubiquitination. Other names for this target antigen include ring finger protein 219. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.