Anti-VPS50 subunit of EARP/GARPII complex antibodies are used for the immunodetection of the protein encoded by the VPS50 gene. In humans, the canonical protein has a reported length of 964 amino acid residues and a mass of 111.2 kDa. Its subcellular localization is in the endosome. Alternative splicing is reported to yield 3 different isoforms for this protein. It is found to be widely expressed, with higher expression in the brain and skeletal muscle. A member of the Syndetin protein family, it is known to act as component of the EARP complex that is involved in endocytic recycling. The gene encoding this protein is implicated in Neurodevelopmental disorder with microcephaly, seizures, and neonatal cholestasis. Other names for this target antigen include EARP/GARPII complex subunit VPS50, VPS50, EARP/GARPII complex subunit, coiled-coil domain containing 132, coiled-coil domain-containing protein 132, and syndetin. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.