Anti-PNKD metallo-beta-lactamase domain containing antibodies are used for the immunodetection of the protein encoded by the PNKD gene. In humans, the canonical protein has a reported length of 385 amino acid residues and a mass of 42.9 kDa. Its subcellular localization is in the membrane, nucleus, mitochondria, and cytoplasm. Alternative splicing is reported to yield 4 different isoforms for this protein. A member of the Glyoxalase II protein family, it is a suspected hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. The gene encoding this protein is implicated in Dystonia. Other names for this target antigen include DYT8, FKSG19, FPD1, KIPP1184, MR-1, MR-1S, MR1, and BRP17. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.