Anti-DENN domain containing 2B antibodies are used for the immunodetection of the protein encoded by the DENND2B gene. In humans, the canonical protein has a reported length of 1137 amino acid residues and a mass of 126.5 kDa. Its subcellular localization is in the cell membrane, cytoplasmic vesicles, and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be widely expressed with the exception of peripheral blood lymphocytes. It is suspected to be involved in cytoskeletal organization and tumorogenicity. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include ST5, p126, DENN domain-containing protein 2B, DENN/MADD domain containing 2B, heLa tumor suppression 1, and HTS1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.