Anti-TUB like protein 3 antibodies are used for the immunodetection of the protein encoded by the TULP3 gene. In humans, the canonical protein has a reported length of 442 amino acid residues and a mass of 49.6 kDa. Its subcellular localization is in the cell membrane, nucleus, cytoplasm, and is secreted. Alternative splicing is reported to yield 3 different isoforms for this protein. It is notably expressed at high levels in testis, ovaries, thyroid, and spinal chord. A member of the TUB protein family, it is a reported regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Other names for this target antigen include TUBL3, tubby-related protein 3, tubby like protein 3, and HRCDF. Gene orthologs have been identified in the mouse, rat, bovine, frog and chimpanzee species.