Anti-gamma-aminobutyric acid type A receptor subunit gamma 2 antibodies are used for the immunodetection of the protein encoded by the GABRG2 gene. In humans, the canonical protein has a reported length of 467 amino acid residues and a mass of 54.2 kDa. Its subcellular localization is in the cytoplasmic vesicles and cell membrane. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the Ligand-gated ion channel (TC 1.A.9) protein family, it is known to be involved with post-embryonic development and signal transduction pathways. Post-translational modifications have been described, including glycosylation and palmitoylation. The gene encoding this protein is implicated in Developmental and epileptic encephalopathy. Other names for this target antigen include DEE74, ECA2, EIEE74, GEFSP3, gamma-aminobutyric acid receptor subunit gamma-2, and CAE2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.