Anti-heat shock protein nuclear import factor hikeshi antibodies are used for the immunodetection of the protein encoded by the HIKESHI gene. In humans, the canonical protein has a reported length of 197 amino acid residues and a mass of 21.6 kDa. Its subcellular localization is in the nucleus and cytoplasm. A member of the OPI10 protein family, it is known to act as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. The gene encoding this protein is implicated in Leukodystrophy. Other names for this target antigen include HLD13, HSPC138, HSPC179, L7RN6, OPI10, and C11orf73. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.