Anti-OCRL inositol polyphosphate-5-phosphatase antibodies are used for the immunodetection of the protein encoded by the OCRL gene. In humans, the canonical protein has a reported length of 901 amino acid residues and a mass of 104.2 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Inositol 1,4,5-trisphosphate 5-phosphatase type II protein family, it is known to catalyze the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. The gene encoding this protein is implicated in Lowe oculocerebrorenal syndrome. Other names for this target antigen include Dent-2, INPP5F, LOCR, NPHL2, OCRL-1, OCRL1, inositol polyphosphate 5-phosphatase OCRL, and DENT2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.