Anti-cleavage factor polyribonucleotide kinase subunit 1 antibodies are used for the immunodetection of the protein encoded by the CLP1 gene. In humans, the canonical protein has a reported length of 425 amino acid residues and a mass of 47.6 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Clp1 protein family, it is reported to be a polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. The gene encoding this protein is implicated in Pontocerebellar hypoplasia. Other names for this target antigen include hClp1, polyribonucleotide 5'-hydroxyl-kinase Clp1, ATP/GTP-binding protein, cleavage and polyadenylation factor I subunit 1, and HEAB. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.