Anti-TIAM Rac1 associated GEF 1 antibodies are used for the immunodetection of the protein encoded by the TIAM1 gene. In humans, the canonical protein has a reported length of 1591 amino acid residues and a mass of 177.5 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the TIAM protein family, it is known to be involved with GTPase activation and cell migration. Post-translational modifications have been described, including ubiquitination. The gene encoding this protein is implicated in Neurodevelopmental disorder with language delay and seizures. Other names for this target antigen include rho guanine nucleotide exchange factor TIAM1, T cell lymphoma invasion and metastasis 1, T-lymphoma invasion and metastasis-inducing protein 1, and NEDLDS. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.