Anti-abhydrolase domain containing 12, lysophospholipase antibodies are used for the immunodetection of the protein encoded by the ABHD12 gene. In humans, the canonical protein has a reported length of 398 amino acid residues and a mass of 45.1 kDa. Its subcellular localization is in the ER. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the Serine esterase protein family, it is known to be involved with the metabolism of lipids. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract. Other names for this target antigen include BEM46L2, C20orf22, PHARC, dJ965G21.2, hABHD12, and ABHD12A. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.