Anti-alkB homolog 3, alpha-ketoglutarate dependent dioxygenase antibodies are used for the immunodetection of the protein encoded by the ALKBH3 gene. In humans, the canonical protein has a reported length of 286 amino acid residues and a mass of 33.4 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is ubiquitously expressed across many tissue types. A member of the AlkB protein family, it is a reported dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Post-translational modifications have been described, including ubiquitination. Other names for this target antigen include alkB, alkylation repair homolog 3, alkylated DNA repair protein alkB homolog 3, prostate cancer antigen-1, and alpha-ketoglutarate-dependent dioxygenase alkB homolog 3. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.