Anti-SRY-box transcription factor 1 antibodies are used for the immunodetection of the protein encoded by the SOX1 gene. In humans, the canonical protein has a reported length of 391 amino acid residues and a mass of 39 kDa. Its subcellular localization is in the nucleus. It is reported to be mainly expressed in the developing central nervous system. It is known to be a type of transcriptional activator. Other names for this target antigen include SRY (sex determining region Y)-box 1, SRY-box 1, SRY-related HMG-box gene 1, and transcription factor SOX-1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.