Anti-VRK serine/threonine kinase 2 antibodies are used for the immunodetection of the protein encoded by the VRK2 gene. In humans, the canonical protein has a reported length of 508 amino acid residues and a mass of 58.1 kDa. Its subcellular localization is in the nucleus, mitochondria, ER, and cytoplasm. Alternative splicing is reported to yield 5 different isoforms for this protein. A member of the CK1 Ser/Thr protein kinase protein family, it is reported to be a serine/threonine kinase that regulates several signal transduction pathways. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include vaccinia related kinase 2, vaccinia virus B1R-related kinase 2, and serine/threonine-protein kinase VRK2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.