Anti-gamma-aminobutyric acid type A receptor subunit beta1 antibodies are used for the immunodetection of the protein encoded by the GABRB1 gene. In humans, the canonical protein has a reported length of 474 amino acid residues and a mass of 54.2 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Ligand-gated ion channel (TC 1.A.9) protein family, it is a known component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Developmental and epileptic encephalopathy. Other names for this target antigen include EIEE45, gamma-aminobutyric acid receptor subunit beta-1, gamma-aminobutyric acid (GABA) A receptor, beta 1, gamma-aminobutyric acid type A receptor beta1 subunit, and DEE45. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.