Anti-sodium channel epithelial 1 subunit beta antibodies are used for the immunodetection of the protein encoded by the SCNN1B gene. In humans, the canonical protein has a reported length of 640 amino acid residues and a mass of 72.7 kDa. Its subcellular localization is in the cytoplasmic vesicles and cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is notably expressed in the placenta, lung and kidney. A member of the Amiloride-sensitive sodium channel (TC 1.A.6) protein family, it is known to be involved with muscle contraction. Post-translational modifications have been described, including N-glycosylation and phosphorylation. The gene encoding this protein is implicated in Pseudohypoaldosteronism. Other names for this target antigen include ENaCb, ENaCbeta, LIDLS1, PHA1B2, SCNEB, beta-ENaC, beta-NaCH, and BESC1. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.