Anti-gamma-aminobutyric acid type A receptor subunit beta3 antibodies are used for the immunodetection of the protein encoded by the GABRB3 gene. In humans, the canonical protein has a reported length of 473 amino acid residues and a mass of 54.1 kDa. Its subcellular localization is in the cytoplasmic vesicles and cell membrane. Alternative splicing is reported to yield 4 different isoforms for this protein. A member of the Ligand-gated ion channel (TC 1.A.9) protein family, it is known to be involved with chemical synaptic transmission and signal transduction pathways. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Epilepsy. Other names for this target antigen include ECA5, EIEE43, gamma-aminobutyric acid receptor subunit beta-3, GABA-alpha receptor beta-2 subunit, and DEE43. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.