Anti-NKD inhibitor of WNT signaling pathway 2 antibodies are used for the immunodetection of the protein encoded by the NKD2 gene. In humans, the canonical protein has a reported length of 451 amino acid residues and a mass of 50.1 kDa. Its subcellular localization is in the cell membrane, cytoplasmic vesicles, and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in the kidney, lung, pancreas and spleen. A member of the NKD protein family, it is known to be involved with exocytosis and the regulation of Wnt signaling pathways. Post-translational modifications have been described, including ubiquitination. Other names for this target antigen include Dvl-binding protein NKD2, NKD2, WNT signaling pathway inhibitor, naked cuticle homolog 2, and protein naked cuticle homolog 2. Gene orthologs have been identified in the mouse, rat, bovine, zebrafish and chimpanzee species.