Anti-NPHS1 adhesion molecule, nephrin antibodies are used for the immunodetection of the protein encoded by the NPHS1 gene. In humans, the canonical protein has a reported length of 1241 amino acid residues and a mass of 134.7 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is notably expressed in podocytes of kidney glomeruli. A member of the Immunoglobulin protein superfamily, it is believed to play a role in the development or function of the kidney glomerular filtration barrier. Post-translational modifications have been described, including phosphorylation and glycosylation. The gene encoding this protein is implicated in Nephrotic syndrome. Other names for this target antigen include NPHN, nephrin, NPHS1, nephrin, nephrosis 1, congenital, Finnish type (nephrin), renal glomerulus-specific cell adhesion receptor, and CNF. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.