Anti-HPS5 biogenesis of lysosomal organelles complex 2 subunit 2 antibodies are used for the immunodetection of the protein encoded by the HPS5 gene. In humans, the canonical protein has a reported length of 1129 amino acid residues and a mass of 127.4 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is widely expressed across many tissue types. A member of the HPS5 protein family, it is believed to regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. The gene encoding this protein is implicated in Hermansky-Pudlak syndrome. Other names for this target antigen include BLOC2S2, BLOC-2 complex member HPS5, Hermansky-Pudlak syndrome 5 protein, alpha integrin binding protein 63, ruby-eye protein 2 homolog, and AIBP63. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.