Anti-isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta antibodies are used for the immunodetection of the protein encoded by the IDH3B gene. In humans, the canonical protein has a reported length of 385 amino acid residues and a mass of 42.2 kDa. Its subcellular localization is in the mitochondria. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the Isocitrate and isopropylmalate dehydrogenases protein family, it is known to play a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The gene encoding this protein is implicated in Retinitis pigmentosa. Other names for this target antigen include isocitrate dehydrogenase [NAD] subunit beta, mitochondrial, NAD(+)-specific ICDH subunit beta, isocitrate dehydrogenase (NAD(+)) 3 beta, isocitrate dehydrogenase 3 (NAD(+)) beta, and RP46. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.