Anti-metabolism of cobalamin associated C antibodies are used for the immunodetection of the protein encoded by the MMACHC gene. In humans, the canonical protein has a reported length of 282 amino acid residues and a mass of 31.7 kDa. Its subcellular localization is in the cytoplasm. It is widely expressed across many tissue types. A member of the MMACHC protein family, it is known to be involved with metabolic processes. The gene encoding this protein is implicated in Methylmalonic aciduria and homocystinuria. Other names for this target antigen include cyanocobalamin reductase / alkylcobalamin dealkylase, alkylcobalamin:glutathione S-alkyltransferase, cyanocobalamin reductase (cyanide-eliminating), and cblC. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.