Anti-macrophage erythroblast attacher, E3 ubiquitin ligase antibodies are used for the immunodetection of the protein encoded by the MAEA gene. In humans, the canonical protein has a reported length of 396 amino acid residues and a mass of 45.3 kDa. Its subcellular localization is in the cell membrane, nucleus, and cytoplasm. Alternative splicing is reported to yield 5 different isoforms for this protein. It is an important component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Post-translational modifications have been described, including ubiquitination. Other names for this target antigen include EMP, GID9, HLC-10, P44EMLP, PIG5, and EMLP. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.