Anti-notch receptor 4 antibodies are used for the immunodetection of the protein encoded by the NOTCH4 gene. In humans, the canonical protein has a reported length of 2003 amino acid residues and a mass of 209.6 kDa. Its subcellular localization is in the nucleus and cell membrane. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the NOTCH protein family, it is known to function as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Post-translational modifications have been described, including glycosylation, protein cleavage and phosphorylation. Other names for this target antigen include neurogenic locus notch homolog protein 4, Notch homolog 4, and INT3. Gene orthologs have been identified in the mouse, rat, bovine, frog and chimpanzee species.