Anti-trafficking from ER to golgi regulator antibodies are used for the immunodetection of the protein encoded by the TFG gene. In humans, the canonical protein has a reported length of 400 amino acid residues and a mass of 43.4 kDa. Its subcellular localization is in the ER. Alternative splicing is reported to yield 4 different isoforms for this protein. It is ubiquitously expressed across many tissue types. It is reported to play a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. The gene encoding this protein is implicated in Neuropathy. Other names for this target antigen include SPG57, TF6, TRKT3, protein TFG, TRK-fused, TRK-fused gene protein, TRKT3 oncogene, and HMSNP. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.