Anti-PARN like ribonuclease domain containing exonuclease 1 antibodies are used for the immunodetection of the protein encoded by the PNLDC1 gene. In humans, the canonical protein has a reported length of 520 amino acid residues and a mass of 60.1 kDa. Its subcellular localization is in the ER. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the CAF1 protein family, it is a reported 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. The gene encoding this protein is implicated in Spermatogenic failure. Other names for this target antigen include PARN like, ribonuclease domain containing 1, PARN-like domain-containing protein 1, poly(A)-specific ribonuclease (PARN)-like domain containing 1, and poly(A)-specific ribonuclease PNLDC1. Gene orthologs have been identified in the mouse, rat, bovine, chimpanzee and chicken species.