Anti-MAGUK p55 scaffold protein 3 antibodies are used for the immunodetection of the protein encoded by the MPP3 gene. In humans, the canonical protein has a reported length of 585 amino acid residues and a mass of 66.2 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in retina at the subapical region (SAR) adjacent to adherens junctions at the OLM, and at the OPL. A member of the MAGUK protein family, it is reported to participate in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K). Other names for this target antigen include MAGUK p55 subfamily member 3, discs, large homolog 3, membrane palmitoylated protein 3, membrane protein palmitoylated 3, membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3), and DLG3. Gene orthologs have been identified in the mouse, rat, bovine, chimpanzee and chicken species.