Anti-HR lysine demethylase and nuclear receptor corepressor antibodies are used for the immunodetection of the protein encoded by the HR gene. In humans, the canonical protein has a reported length of 1189 amino acid residues and a mass of 127.5 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be a histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. The gene encoding this protein is implicated in Alopecia universalis congenita. Other names for this target antigen include [histone H3]-dimethyl-L-lysine(9) demethylase hairless, hair growth associated, hairless homolog, protein hairless, and lysine-specific demethylase hairless. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species.