Anti-SHOC2 leucine rich repeat scaffold protein antibodies are used for the immunodetection of the protein encoded by the SHOC2 gene. In humans, the canonical protein has a reported length of 582 amino acid residues and a mass of 64.9 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the SHOC2 protein family, it is a regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. The gene encoding this protein is implicated in Noonan syndrome-like disorder with loose anagen hair. Other names for this target antigen include SIAA0862, SOC2, SUR8, leucine-rich repeat protein SHOC-2, soc-2 suppressor of clear homolog, and NSLH1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.