Anti-SRY-box transcription factor 17 antibodies are used for the immunodetection of the protein encoded by the SOX17 gene. In humans, the canonical protein has a reported length of 414 amino acid residues and a mass of 44.1 kDa. Its subcellular localization is in the nucleus. It is reported to be expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. It is known to act as transcription regulator that binds target promoter DNA and bends the DNA. The gene encoding this protein is implicated in Vesicoureteral reflux. Other names for this target antigen include SRY (sex determining region Y)-box 17, SRY-box 17, SRY-related HMG-box transcription factor SOX17, and transcription factor SOX-17. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species.