Anti-metabolism of cobalamin associated D antibodies are used for the immunodetection of the protein encoded by the MMADHC gene. In humans, the canonical protein has a reported length of 296 amino acid residues and a mass of 32.9 kDa. Its subcellular localization is in the mitochondria and cytoplasm. It is found to be widely expressed at high levels. It is known to be involved in cobalamin metabolism and trafficking. The gene encoding this protein is implicated in Methylmalonic aciduria and homocystinuria. Other names for this target antigen include CL25022, cblD, cobalamin trafficking protein CblD, methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria, and C2orf25. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.