Anti-protein tyrosine phosphatase receptor type E antibodies are used for the immunodetection of the protein encoded by the PTPRE gene. In humans, the canonical protein has a reported length of 700 amino acid residues and a mass of 80.6 kDa. Its subcellular localization is in the cell membrane and cytoplasm. It is reported to be expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells). A member of the Protein-tyrosine phosphatase protein family, it is known to be involved with protein dephosphorylation. Post-translational modifications have been described, including glycosylation, protein cleavage and phosphorylation. Other names for this target antigen include PTPE, R-PTP-EPSILON, receptor-type tyrosine-protein phosphatase epsilon, protein tyrosine phosphatase, receptor type, epsilon polypeptide, and HPTPE. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.