Anti-helicase for meiosis 1 antibodies are used for the immunodetection of the protein encoded by the HFM1 gene. In humans, the canonical protein has a reported length of 1435 amino acid residues and a mass of 162.6 kDa. Alternative splicing is reported to yield 2 different isoforms for this protein. It is found to be highly expressed in the testis and ovary. A member of the Helicase protein family, it is known to be required for crossover formation and complete synapsis of homologous chromosomes during meiosis. The gene encoding this protein is implicated in Premature ovarian failure. Other names for this target antigen include HFM1, ATP dependent DNA helicase homolog, SEC63 domain-containing protein 1, helicase-like protein HFM1, and probable ATP-dependent DNA helicase HFM1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.