Anti-protein tyrosine phosphatase non-receptor type 6 antibodies are used for the immunodetection of the protein encoded by the PTPN6 gene. In humans, the canonical protein has a reported length of 595 amino acid residues and a mass of 67.6 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 4 different isoforms for this protein. A member of the Protein-tyrosine phosphatase protein family, it is known to be involved with cell differentiation and cytokine-mediated signaling pathways. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, and HCP. Gene orthologs have been identified in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species.