Anti-gamma-aminobutyric acid type A receptor subunit alpha2 antibodies are used for the immunodetection of the protein encoded by the GABRA2 gene. In humans, the canonical protein has a reported length of 451 amino acid residues and a mass of 51.3 kDa. Its subcellular localization is in the cytoplasmic vesicles and cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Ligand-gated ion channel (TC 1.A.9) protein family, it is known to be involved with signal transduction pathways. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Developmental and epileptic encephalopathy. Other names for this target antigen include EIEE78, gamma-aminobutyric acid receptor subunit alpha-2, GABA(A) receptor subunit alpha-2, gamma-aminobutyric acid type A receptor alpha2 subunit, and DEE78. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.