Anti-protein tyrosine phosphatase non-receptor type 1 antibodies are used for the immunodetection of the protein encoded by the PTPN1 gene. In humans, the canonical protein has a reported length of 435 amino acid residues and a mass of 50 kDa. Its subcellular localization is in the ER and cell membrane. It is reported to be expressed in keratinocytes. A member of the Protein-tyrosine phosphatase protein family, it is reported to be a tyrosine-protein phosphatase, which acts as a regulator of endoplasmic reticulum unfolded protein response. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include tyrosine-protein phosphatase non-receptor type 1, protein tyrosine phosphatase, placental, protein-tyrosine phosphatase 1B, and PTP1B. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.