Anti-jagged canonical Notch ligand 1 antibodies are used for the immunodetection of the protein encoded by the JAG1 gene. In humans, the canonical protein has a reported length of 1218 amino acid residues and a mass of 133.8 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is found to be widely expressed in adult and fetal tissues. It is noted to be involved in angiogenesis. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Alagille syndrome. Other names for this target antigen include AGS and AGS1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.