Anti-notch receptor 1 antibodies are used for the immunodetection of the protein encoded by the NOTCH1 gene. In humans, the canonical protein has a reported length of 2555 amino acid residues and a mass of 272.5 kDa. Its subcellular localization is in the nucleus and cell membrane. A member of the NOTCH protein family, it is known to function as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Post-translational modifications have been described, including O-glycosylation, ubiquitination, protein cleavage and phosphorylation. The gene encoding this protein is implicated in Aortic valve disease. Other names for this target antigen include AOVD1, TAN1, hN1, neurogenic locus notch homolog protein 1, Notch homolog 1, translocation-associated, and AOS5. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.