Anti-sprouty-related EVH1 domain containing 3 antibodies are used for the immunodetection of the protein encoded by the SPRED3 gene. In humans, the canonical protein has a reported length of 410 amino acid residues and a mass of 42.7 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is noted to be involved in the regulation of cell differentiation. Post-translational modifications have been described, including ubiquitination, palmitoylation and phosphorylation. Other names for this target antigen include sprouty-related, EVH1 domain-containing protein 3. Gene orthologs have been identified in the mouse, rat, bovine, frog and chimpanzee species.